I feel very sleepy after taking progesterone and want to sleep.

Disease science

I Feel Very Sleepy After Taking Progesterone and Want to Sleep


Progesterone is a hormone that is produced by the ovaries during the second half of the menstrual cycle. It helps to prepare the uterus for pregnancy by thickening the uterine lining and increasing blood flow to the uterus. Progesterone also has a sedative effect, which can make you feel sleepy after taking it.

Why does progesterone make me sleepy?

Progesterone binds to receptors in the brain that are involved in sleep regulation. This binding can increase the activity of GABA, a neurotransmitter that promotes sleep. Progesterone also reduces the activity of glutamate, a neurotransmitter that promotes wakefulness.

How long does it take for progesterone to make me sleepy?

The sedative effects of progesterone can start within 30 minutes of taking it. However, it may take longer for you to feel sleepy if you are taking progesterone for the first time or if you are taking a high dose.

How long will I feel sleepy after taking progesterone?

The sedative effects of progesterone will usually last for 4-8 hours. However, some people may feel sleepy for longer or shorter periods of time.

What can I do to reduce the sleepiness caused by progesterone?

There are a few things you can do to reduce the sleepiness caused by progesterone, including:

Taking progesterone at night before bed

Taking a lower dose of progesterone

Avoiding caffeine and alcohol before bed

Getting regular exercise

Eating a healthy diet

Getting enough sleep

When should I call my doctor?

You should call your doctor if you are experiencing severe sleepiness after taking progesterone. This could be a sign of a more serious medical condition, such as a sleep disorder or a hormonal imbalance.

Other side effects of progesterone

In addition to sleepiness, progesterone can also cause other side effects, including:


Breast tenderness


Mood swings


These side effects are usually mild and will go away within a few days or weeks. However, if you are experiencing any severe side effects, you should call your doctor.

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